Faculty
Augustine M. K. Choi, M.D.
Chief, Division of Pulmonary and Critical Care (BWH)
Specialty: Pulmonary and Critical Care Medicine
Brigham and Women's Hospital
15 Francis Street
Boston, MA 02115
Publications
The following is a selection of publications for which this Partners Asthma Center physician has been cited as an author in PubMed databases.
Alam J, Camhi S, Choi AMK. Identification of a second region upstream of the mouse HO-1 gene that functions as a basal level and inducer-dependent transcriptional enhancer. J Biol Chem. 270:11977-84, 1995.
Lee PJ, Alam J, Wiegand GW, Choi AMK. Overexpression of heme oygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA. 93:10393-98, 1996.
Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AMK. Hypoxia inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem. 272:5375-81, 1997.
Hartsfield CL, Alam J and Choi AMK. Transcriptional regulation of heme oxygenase-1 gene by pyrrolidine dithiocarbamate. FASEB J. 12:1675-82, 1998.
Soares MP, Lin Y, Anrather J, Csizmadia E, Takigami K, Sato K, Grey ST, Colvin RB, Choi AMK, Poss KD, Bach FH. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med. 4:1073-7, 1998.
Alam J, Stewart D, Touchard C, Boinapally S, Choi AMK, Cook JL. Nrf2, a Cap’ n’ Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem. 274: 26071-78. 1999.
Chin BY, Petrache I, Choi AMK Choi ME. Transforming growth factor-B1 rescues serum deprivation induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages. J Biol Chem. 274:11362-68, 1999.
Otterbein LE, Mantell LL, Choi AMK. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 276:L688-94, 1999.
Otterbein LE, Kolls JK, Mantell LL, Cook JL, Alam J, Choi AMK. Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. J Clin Inv.103: 1047-54, 1999.
Alam J, Wicks C, Stewart D, Gong P, Touchard C, Otterbein S, Choi AMK, Burrow ME, Tou J. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J Biol Chem. 275: 27694-702, 2000.
Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AMK. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med, 6:422-8, 2000.
Brouard S, Otterbein LE, Anrather J, Tobiasch E, Bach FH, Choi AMK*, Soares MP*. Carbon monoxide generated by heme oxygenase-1 suppresses endothelial cell apoptosis. J Exp Med. 192: 1015-26, 2000 (* equal contributors as senior authors).
Chapman JT, Otterbein LE, Elias JA, Choi AMK. Carbon monoxide attenuates aeroallergen-induced inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 281: L209-16, 2001.
He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AMK, Alam J. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem. 276:20858-65, 2001 (Choi and Alam: equal contributors as senior authors). .
Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AMK, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem. 278:1248-58, 2003.
Otterbein LE, Haga M, Zuckerbraun BS, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FB, Choi AMK, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 9:183-90, 2003 (Choi and Bach; Co-Corresponding author).
Song R, Kubo M, Morse D, Zhou Z, Zhang X, Dauber JH, Fabisiak J, Alber SM, Watkins SC, Zuckerbraun B, Otterbein LE, Ning W, Oury TD, Lee PJ, McCurry KR, Choi AMK. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol. 163:231-42, 2003.
Zuckerbraun BS, Billiar TR, Otterbein SL, Kim PK, Liu F, Choi AMK, Bach FH, Otterbein LE. Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med. 198:1707-16, 2003.
Wang X, Ryter SW, Dai C, Tang ZL, Watkins SC, Yin XM, Song R, Choi AMK. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J Biol Chem. 278:29184-91, 2003.
Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AMK. Suppression of inflammatory cytokine production by carbon monoxide involves the c-Jun NH2 terminal kinase (JNK) pathway and AP-1. J Biol Chem. 278: 36993-8, 2003.
Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse D, Fearns C, Ulevitch R, Knickelbein R, Flavel RA, Choi AMK. MKK3 Mitogen-Activated Protein Kinase Pathway Mediates Carbon Monoxide-Induced Protection Against Oxidant-Induced Lung Injury. Am J Pathol. 163:2555-63, 2003.
Wang X, Zhou Y, Kim HP, Song R, Zarnegar R, Ryter SW, Choi AMK. Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J Biol Chem. 279:5237-43, 2004.
Song R, Mahidhara RS, Zhou Z, Hoffman RA, Seol DW, Flavell RA, Billiar TR, Otterbein LE, Choi AMK. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J Immunol. 172:1220-6, 2004.
Dolinay T, Szilasi, M, Siu M, Choi AMK. Inhaled carbon monoxide confers anti-inflammatory effects against ventilator-induced lung injury. Am J Respir Crit Care Med 170:613-20, 2004.
Song R, Zhou Z, Kim PK, Shapiro RA, Liu F, Ferran C, Choi AMK, Otterbein LE. Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. J Biol Chem. 279:44327-34, 2004.
Kim HP, Wang X, Galbiati F, Ryter SW, Choi AMK. Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 18:1080-9, 2004
Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AMK. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA. 101:14895-900, 2004.
Wang X, Wang Y, Zhang J, Kim HP, Ryter SW, Choi AMK. FLIP protects against Hypoxia/Reoxygenation-Induced Endothelial Cell Apoptosis by Inhibiting Bax Activation. Mol Cell Biol. 25:4742-51, 2005.
Kim HP, Wang X, Zhang J, Suh GY, Benjamin IJ, Ryter SW, Choi AMK. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38b MAPK and heat shock factor-1. J Immunol. 175(4):2662-9, 2005.
Kim HP, Wang X , Nakao A, Kim SI, Murase N, Choi ME, Ryter S, Choi AMK. Caveolin-1 Expression by Mitogen Means of p38b mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proc Natl Acad Sci USA. 102(32):11319-24, 2005.
Nakahira, K, Kim HP, Geng VH, Nakao A, Wang X, Murase N, Drain PF, Wang X, Sasidhar M, Nabel EG, Takahashi T, Lukacs NW, Ryter SW, Morita K, Choi AMK. Carbon monoxide differentially inhibits TLRs signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J. Exp. Med. 203(10):2377-89, 2006.
Wang X, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick C, Liu F, Ifedigbo E, Xu X, Oury TD, Kaminski N, Choi AMK. Caveolin-1: A critical regulator of lung fibrosis in idiopathic lung fibrosis. J Exp Med. 203(13):2895-906., 2006.
Wang X, Wang Y, Kim HP, Nakahira K, Ryter SW, Choi AMK. Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation.
J Biol Chem. Jan 19;282(3):1718-26, 2007
